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Anti Active Caspase-3 - IMMUNOSTEP. WE KNOW HOW

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Anti Active Caspase-3 - IMMUNOSTEP. WE KNOW HOW

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Anti Active Caspase-3 - IMMUNOSTEP. WE KNOW HOW

商品详情参考文献相关资料

PURE - anti Human Anti Active Caspase-3 -

Reference	Size	Price	Quantity	Add to cart
CAS3PU	0,1 ml	139,70 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

CAS3PU

0,1 ml

139,70 € tax excl.

Product Description

Tested Applications: WB
Conjugated: PURE
Immunogen: synthetic peptide (KLH-conjugated) corresponding to amino terminal residues adjacent to Asp175 of human caspase-3.
Species Reactivity: Human
Storage Buffer: PBS, 0,09% sodium Azide, may contain carrier protein-stabilizer
Regulatory Status: RUO

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Large description:

Caspases are a family of cytosolic aspartate specific cysteine proteases involved in apoptosis and inflammation. Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a key protease that is activated during the early stages of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins during apoptosis, such as ply (APD-ribose) polymerase (PARP). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which is derived from the 32 kDa proenzyme and associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9).

References:

Caraballo JM et al. High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. Oncotarget. 2014 Jul; 5(13): 4694–4708.

Other names: CASP3, CPP32
GeneID: 836
Molecular weight: 17 kDa.