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Anti-FBL Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

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Anti-FBL Antibody

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Overview

Name:	Anti-FBL Antibody See all FBL primary antibodies
Description:	Goat polyclonal antibody to FBL.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human FBL (internal region).
Sequence:	CRGKEDALVTKN
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
Sequence Similarities:	Belongs to the methyltransferase superfamily. Fibrillarin family.
Post-Translational Modification:	By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
Cellular locations:	Nucleus > Nucleolus. Fibrillar region of the nucleolus.
Database Links:	Entrez Gene: 2091 Human Omim: 134795 Human SwissProt: P22087 Human Unigene: 299002 Human
Synonyms:	34 kD nucleolar scleroderma antigen Antibody 34 kDa nucleolar scleroderma antigen Antibody Fbl Antibody FBRL_HUMAN Antibody FIB Antibody FIB1 Antibody Fibrillarin Antibody FLRN Antibody Histone-glutamine methyltransferase Antibody Nop1p Antibody RNA U3 small nucleolar interacting protein 1 Antibody RNU3IP1 Antibody rRNA 2' O methyltransferase fibrillarin Antibody rRNA 2'-O-methyltransferase fibrillarin Antibody
Information:	Target information shown above is from the UniProt Consortium.