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Anti-Cystatin A (G84) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Cystatin A (G84) Antibody

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Name:	Anti-Cystatin A (G84) Antibody See all Cystatin A primary antibodies
Description:	Rabbit polyclonal antibody to Cystatin A (G84)
Specificity:	Cystatin A (G84) pAb detects endogenous levels of Cystatin A protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 51-100 of Human Cystatin A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 11 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
Tissue Specificity:	Expressed in the skin throughout the epidermis.
Involvement in Disease:	Peeling skin syndrome 4: A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.
Sequence Similarities:	Belongs to the cystatin family.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 1475?Human Entrez Gene: 209294?Mouse Entrez Gene: 288075?Rat Omim: 184600?Human SwissProt: P01040?Human SwissProt: P56567?Mouse SwissProt: P01039?Rat Unigene: 518198?Human Unigene: 300592?Mouse Unigene: 78016?Rat
Synonyms:	AREI Antibody cstA Antibody Cystatin A Antibody Cystatin AS Antibody Cystatin-A Antibody Cystatin-AS Antibody CYTA_HUMAN Antibody Stefin A Antibody Stefin-A Antibody STF1 Antibody STFA Antibody
Information:	Target information shown above is from the UniProt Consortium.