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Anti-CXCR-3 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CXCR-3 Antibody

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Overview

Name:	Anti-CXCR-3 Antibody See all CXCR-3 primary antibodies
Description:	Rabbit polyclonal antibody to CXCR-3
Specificity:	CXCR-3 pAb detects endogenous levels of CXCR-3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human CXCR-3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 40 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
Tissue Specificity:	Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification:	Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 2833?Human Entrez Gene: 12766?Mouse Entrez Gene: 84475?Rat Omim: 300574?Human SwissProt: P49682?Human SwissProt: O88410?Mouse SwissProt: Q9JII9?Rat Unigene: 198252?Human Unigene: 12876?Mouse Unigene: 24787?Rat
Synonyms:	C-X-C chemokine receptor type 3 Antibody CD 183 Antibody CD182 Antibody CD183 Antibody Chemokine (C X C motif) receptor 3 Antibody Chemokine (C X C) receptor 3 Antibody Chemokine CXC Motif Receptor 3 Antibody CKR L2 Antibody CKR-L2 Antibody CKRL2 Antibody CMKAR3 Antibody CXC-R3 Antibody CXCR-3 Antibody CXCR3 Antibody CXCR3_HUMAN Antibody G Protein Coupled Receptor 9 Antibody G protein-coupled receptor 9 Antibody GPR9 Antibody Interferon-inducible protein 10 receptor Antibody IP-10 receptor Antibody IP10 Antibody IP10 R Antibody IP10 receptor Antibody IP10-R Antibody IP10R Antibody Mig R Antibody Mig receptor Antibody Mig-R Antibody MIGR Antibody
Information:	Target information shown above is from the UniProt Consortium.