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Anti-TRPA1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-TRPA1 Antibody

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Overview

Name:	Anti-TRPA1 Antibody See all TRPA1 primary antibodies
Description:	Rabbit polyclonal antibody to TRPA1.
Applications:	WB
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Mouse
Immunogen:	A synthetic peptide of human TRPA1.
Protein Length:	1119
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
Tissue Specificity:	Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Involvement in Disease:	Episodic pain syndrome, familial, 1: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes.
Sequence Similarities:	Belongs to the transient receptor (TC 1.A.4) family.
Post-Translational Modification:	TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain.
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 277328?Mouse SwissProt: Q8BLA8?Mouse Unigene: 186329?Mouse
Synonyms:	ANKTM 1 Antibody ANKTM1 Antibody Ankyrin-like with transmembrane domains protein 1 Antibody Transformation sensitive protein p120 Antibody Transformation-sensitive protein p120 Antibody Transient receptor potential cation channel subfamily A member 1 Antibody TRPA 1 Antibody TRPA1 Antibody TRPA1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.