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Anti-MLKL Antibody

品牌：Antibodies

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规格：50µl

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Anti-MLKL Antibody

商品详情参考文献相关资料

Name:	Anti-MLKL Antibody See all MLKL primary antibodies
Description:	Rabbit polyclonal antibody to MLKL.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human MLKL.
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Tissue Specificity:	Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.
Sequence Similarities:	Belongs to the protein kinase superfamily.
Post-Translational Modification:	Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Cellular locations:	Cytoplasm. Cell membrane. Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Database Links:	Entrez Gene: 197259?Human Omim: 615153?Human SwissProt: Q8NB16?Human Unigene: 119878?Human
Synonyms:	9130019I15Rik Antibody FLJ34389 Antibody hMLKL Antibody Mixed lineage kinase domain like Antibody Mixed lineage kinase domain like protein Antibody Mixed lineage kinase domain like pseudokinase Antibody Mixed lineage kinase domain-like protein Antibody MLKL Antibody MLKL_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.