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Anti-HXK I Antibody

品牌：Antibodies

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规格：50µl

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Anti-HXK I Antibody

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Name:	Anti-HXK I Antibody See all HXK I primary antibodies
Description:	Rabbit monoclonal antibody to HXK I
Specificity:	This antibody detects endogenous levels of HXK I and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 102 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Tissue Specificity:	Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.
Involvement in Disease:	Hexokinase deficiency: Rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature. Neuropathy, hereditary motor and sensory, Russe type: An autosomal recessive progressive complex peripheral neuropathy characterized by onset in the first decade of distal lower limb weakness and muscle atrophy resulting in walking difficulties. Distal impairment of the upper limbs usually occurs later, as does proximal lower limb weakness. There is distal sensory impairment, with pes cavus and areflexia. Laboratory studies suggest that it is a myelinopathy resulting in reduced nerve conduction velocities in the demyelinating range as well as a length-dependent axonopathy.
Sequence Similarities:	Belongs to the hexokinase family.
Cellular locations:	Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.