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Anti-TIRAP Antibody

品牌：Antibodies

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规格：100µg

货期：

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Anti-TIRAP Antibody

商品详情参考文献相关资料

Name:	Anti-TIRAP Antibody See all TIRAP primary antibodies
Description:	Goat polyclonal antibody to TIRAP.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human TIRAP (C terminal).
Sequence:	C-EGEGERDSATVSDL
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Tissue Specificity:	Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Post-Translational Modification:	Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.
Cellular locations:	Cytoplasm. Cell membrane. Membrane. Colocalizes with DAB2IP at the plasma membrane.
Database Links:	Entrez Gene: 114609 Human GenBank: AF378129 Human GenBank: AF378130 Human Omim: 606252 Human SwissProt: P58753 Human Unigene: 537126 Human
Synonyms:	Adapter protein wyatt Antibody FLJ42305 Antibody MAL Antibody MyD88 adapter like protein Antibody TIR domain containing adapter protein Antibody TIRAP Antibody Toll interleukin 1 receptor (TIR) domain containing adaptor protein Antibody Toll interleukin 1 receptor domain containing adapter protein Antibody Toll like receptor adaptor protein Antibody Wyatt Antibody
Information:	Target information shown above is from the UniProt Consortium.